Cytochromes - P450 Superfamily Genes - Somewhat Elaborate Posts - Post 1

 

 P450 superfamily genes are subdivided and classified following recommendations of a nomenclature committee on the basis of amino-acid identity, phylogenetic criteria and gene organization. Canonical P450s use electrons from NAD(P)H to catalyze activation of molecular oxygen, leading to regiospecific and stereospecific oxidative attack of a plethora of substrates. The reactions carried out by P450s, though often hydroxylation, can be extremely diverse and sometimes surprising.

 The root symbol CYP is followed by a number for families (generally groups of proteins with more than 40% amino-acid sequence identity, of which there are over 200), a letter for subfamilies (greater than 55% identity) and a number for the gene; such as, CYP4U2.

 

Cytochrome P450 proteins, named for the absorption band at 450 nm of their carbon-monoxide bound form, are one of the largest superfamilies of enzyme proteins.

 

(To be continued, referenced and aded images to)

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