Lipophilicity - Non-Elaborate Posts - Post 1

 

 

Lipophilicity is a chemical property that describes how strongly a molecule tends to dissolve in or associate with nonpolar environments such as oils, fats, or lipid membranes, rather than in polar environments like water. In simpler terms, a lipophilic compound “likes” lipids (fats) more than water. Lipophilicity is essentially the measure of how much a compound prefers to interact with nonpolar, hydrophobic environments compared to polar, aqueous environments. Molecules with high lipophilicity dissolve easily in fats, oils, cell membranes, and other hydrophobic media, but poorly in water. Those with low lipophilicity (hydrophilic molecules) dissolve better in water but struggle to cross lipid membranes.

 Higher lipophilicity increases drug promiscuity and clearance; thus, lowering the lipophilicity is a common drug design strategy for improving PK properties. Physicochemical properties such as lipophilicity are key determinants of drug-likeness, since they directly impact permeability, solubility, and the ability to reach the site of action.

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