Triazolo- and tetrazolopyrimidyl -Non-elaborate Posts - Post 1


The arrangement of each ring follows the order of the site of fusion on the pyrimidine ring, denoted by the letter t, and the site of fusion on the triazole ring, denoted by the letters x and y. The classification of the subdivisions is dependent upon the extent of published work. There are four possible isomeric structures: (1) 1,2,4-triazolo[4,3-a] pyrimidines, (2) 1,2,4-triazolo[4,3-c]pyrimidines, (3) 1,2,4-triazolo[l,5-a] pyrimidine, and (4) 1,2,4-triazolo[1,5-c] pyrimidines. A characteristic feature triazolopyrimidines is the ease of a Dimroth rearrangement. 1,2-Diaminopyrimidines are general precursors, and they can be generated from 1-amino or 2-aminopyrimidines.

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