Triazolopyrimidine - Triazolopyrimidine Core - Non-Elaborate Posts - Post 2

 

 In agrochemistry, triazolopyrimidine derivatives are widely used as fungicides and herbicides. The fungicidal activity often comes from their ability to interfere with fungal respiration, nucleic acid metabolism, or enzyme activity. For example, some triazolopyrimidine fungicides target mitochondrial respiration in oomycetes, disrupting the energy supply of the pathogen. In herbicides, they frequently act by inhibiting acetolactate synthase (ALS), a key enzyme in the biosynthesis of branched-chain amino acids (valine, leucine, isoleucine). This inhibition starves plants of essential nutrients, leading to controlled weed management. Ametoctradin is a post emergence fungicide used to control major plant pathogens from the Oomycete class.

 Ametoctradin represents a new class of chemistry (triazolopyrimidine) and is a strong inhibitor of mitochondrial respiration in complex III (cytochrome bc1). Products containing ametoctradin are registered for use to control downy mildew, phytophthora blight or crown rot, and late blight. Ametoctradin can be applied as a broadcast, directed, or banded foliar or soil spray and as a soil drench. Two products are co-formulated with the active ingredient dimethomorph, another fungicide.

 

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