Triazolopyrimidyl - Strategies for Syntesis and Derivatives of these Scaffolds - Non-Elaborate Posts - Post 6

 

 

Polyfunctionalization strategies have been explored to generate multifunctional derivatives capable of dual or triple target activity. For instance, hybrid molecules combining triazolopyrimidyl cores with pharmacophores from other heterocyclic families, such as quinolines or thiazoles, create compounds with broadened biological spectra. Such hybrid scaffolds can simultaneously inhibit multiple enzymes or pathways, reducing the likelihood of resistance development in pathogens.

High-throughput synthesis techniques are enabling rapid exploration of scaffold diversity. Combinatorial libraries of triazolopyrimidyl derivatives can be generated through parallel synthesis, allowing hundreds or thousands of analogues to be screened for biological activity. Coupled with computational docking and predictive modeling, these libraries accelerate the identification of lead candidates for both medicinal and agrochemical applications.

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