Triazolopyrimidyl - Syntesis - Non-elaborate Posts - Post 7

 

 

Photoredox catalysis has introduced new avenues for scaffold modification. By harnessing visible light to generate reactive radicals, chemists can functionalize triazolopyrimidyl frameworks at otherwise inert positions. This enables late-stage diversification, a critical tool in medicinal chemistry where subtle modifications can drastically alter pharmacological profiles. The ability to install fluorine, alkyl, or aryl groups selectively reflects the scaffold’s adaptability to cutting-edge synthetic methodologies.

Electrochemical synthesis is another modern development. By applying controlled potentials, oxidative and reductive transformations of triazolopyrimidyl intermediates can be achieved without stoichiometric reagents. This not only reduces chemical waste but also enables unique transformations not easily accessible by thermal or catalytic routes.

 

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