Whilst Y132F strongly associated with high fluconazole MICs; commonly reported ~16–≥64-fold increases in MIC (typical MICs reported in resistant isolates: ≥64 → >128 µg/mL in many studies).

Often raises voriconazole MICs 4–16-fold with reported MICs in resistant isolates of ~1–8 µg/mL (varies). Y132F reduces azole binding affinity in the active site.

Widely reported in clinical isolates worldwide (outbreaks and surveillance collections). Frequently seen in combination with efflux upregulation or other ERG11 substitutions (common in C. albicans and other Candida spp.).

Comments

Post a Comment

Popular posts from this blog

Triazolopyrimidyl - The Structural and Physico-Chemical Properties of these Compounds - Non-Elaborate Posts - Post 9

    The inherent aromaticity of triazolopyrimidyl scaffolds provides a stable backbone for derivatization, however aromaticity is not monolithic.  Substituents can perturb resonance stabilization, influencing both chemical reactivity and biological affinity. Balancing substitution without disrupting the delicate aromatic equilibrium is a continual challenge for chemists optimizing scaffold activity. Tautomerism represents a further dimension of complexity.  Triazolopyrimidyl compounds can exist in multiple tautomeric forms depending on protonation state and solvent environment. These equilibria affect binding interactions, metabolic transformations, and physicochemical readouts. Analytical techniques such as variable-temperature NMR provide crucial windows into tautomeric dynamics.  
Read more

Research unveils Rubik's cube-like Heusler materials with potential for thermoelectric applications

Image
            Researchers from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences have designed Slater-Pauling (S-P) Heusler materials with a unique structure resembling a Rubik's cube. These materials exhibit semiconductor-like properties and have potential in thermoelectric applications.  In traditional semiconductor Heusler alloys, the number of valence electrons follows a specific rule. However, these S-P Heusler compounds defy this rule while still displaying semiconductor behavior.  In this study, the team focused on two Heusler systems: Ti-Fe-Sb and M-Co-Sn (M = Ti, Zr, Hf). Within these two systems, they predicted the thermodynamically stable TiFe 1.5 Sb and MCo 1.33 Sn S-P semiconductors.  he researchers explained the unique properties of these compounds. In addition to the known half-Heusler (HH) and full-Heusler (FH) local geometries, these S-P structures contain defective-HH (DH) and defective-FH (...
Read more

Triazolopyrimidyl - The Structural and Physico-Chemical Properties of these Compounds - Non-Elaborate Posts - Post 10

  The structure–property relationships of triazolopyrimidyl scaffolds epitomize the principle that molecular design is both art and science.  The careful orchestration of substituent placement, electronic tuning, and physicochemical balancing has yielded compounds with enduring significance in both pharmaceutical and agrochemical innovation. Their structural integrity and physicochemical plasticity ensure their continued prominence as one of the most versatile heteroaromatic frameworks in modern chemistry.  
Read more