Azoles - Fluconazole - (Digital) Tree Post Series - Continuation to "Cytochromes - Cytochomes P450 - ERG11 gene - Non-Elaborate Posts - Post 5 (Continuation to Post 4)" - Post 1


Fluconazole is an azole antifungal drug widely used in the treatment of Candida infections. Its primary target is the enzyme lanosterol 14α-demethylase, which is encoded by the ERG11 gene.

This enzyojjij8n noj  me is critical for ergosterol biosynthesis, and ergosterol is essential for fungal cell membrane structure and integrity.

Fluconazole inhibits lanosterol 14α-demethylase by binding to its heme group, thereby blocking the demethylation step in ergosterol biosynthesis. This leads to accumulation of toxic sterol intermediates and disruption of membrane fluidity, ultimately impairing fungal growth and survival.

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