Azoles - Fluconazole - (Digital) Tree Post Series - Continuation to "Cytochromes - Cytochomes P450 - ERG11 gene - Non-Elaborate Posts - Post 5 (Continuation to Post 4)" - Post 5

 

 

The central biochemical effect of ERG11 mutations is reduced drug-binding affinity.

When fluconazole cannot tightly bind, the inhibition of sterol demethylation becomes incomplete, allowing ergosterol synthesis to continue despite drug presence.

Because ergosterol synthesis is not fully blocked, fungal cells maintain more stable membranes, reducing the fungistatic effect of fluconazole. 

This ensures that Candida species survive even under therapeutic drug concentrations.

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