Azoles - Fluconazole - (Digital) Tree Post Series - Continuation to "Cytochromes - Cytochomes P450 - ERG11 gene - Non-Elaborate Posts - Post 5 (Continuation to Post 4)" - Post 6

 

 

ERG11 mutations often confer cross-resistance to other azoles, such as itraconazole and voriconazole, because these drugs share the same binding site on lanosterol 14α-demethylase. This complicates antifugal therapy.

The presence of ERG11 mutations is strongly correlated with clinical treatment failures. Patients with Candida isolates harboring resistant ERG11 alleles often show persistent infections despite fluconazole therapy.


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