Azoles - Fluconazole - (Digital) Tree Post Series - Continuation to "Cytochromes - Cytochomes P450 - ERG11 gene - Non-Elaborate Posts - Post 5 (Continuation to Post 4)" - Post 4

 

 

One of the best-characterized mutations is Y132H. This substitution changes the polarity and structure near the fluconazole-binding site, dramatically lowering drug affinity and conferring resistance. 

Other common substitutions, such as R467K, similarly modify the enzyme’s conformation. Each substitution alters fluconazole binding in a slightly different manner, which leads to varied levels of resistance depending on the exact mutation.


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