Azoles - Fluconazole - (Digital) Tree Post Series - Continuation to "Cytochromes - Cytochomes P450 - ERG11 gene - Non-Elaborate Posts - Post 5 (Continuation to Post 4)" - Post 10

 

 ERG11 mutations profoundly shape the interaction between fluconazole and fungal pathogens. By altering the drug’s target site, these mutations diminish antifungal efficacy, drive treatment failures, and fuel global concerns about resistance. Understanding them at the molecular, clinical, and evolutionary levels is essential for future antifungal strstegies.

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