Azoles - Fluconazole - (Digital) Tree Post Series - Continuation to "Cytochromes - Cytochomes P450 - ERG11 gene - Non-Elaborate Posts - Post 5 (Continuation to Post 4)" - Post 8

 

 

Not all ERG11 mutations are evolutionarily advantageous in the absence of drug pressure. Some confer a fitness cost, such as slower growth or impaired membrane function, which balances their persistence in fungal populations.

Molecular diagnostic methods such as PCR and sequencing are used to identify ERG11 mutations in clinical isolates. These tools are crucial for guiding antifungal therapy in resistant infections.

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