Azoles - Fluconazole - (Digital) Tree Post Series - Continuation to "Cytochromes - Cytochomes P450 - ERG11 gene - Non-Elaborate Posts - Post 5 (Continuation to Post 4)" - Post 7

 

 

Different regions of the world report different ERG11 mutations as dominant. This variation reflects local antifungal usage patterns, evolutionary pressures, and fungal population structures.

From an evolutionary standpoint, ERG11 mutations are a fungal survival strategy under antifungal stress. Populations exposed to repeated fluconazole treatments accumulate resistant alleles, leading to clonal expansion of resistant strains.


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