Cytochromes - Cytochomes P450 - ERG11 gene - Non-Elaborate Posts - Post 8 (Continuation to Post 4 and respectively Post 7)

etc. Post

 Other azoles: Similarly, itraconazole and newer drugs like isavuconazole act on Erg11p. ERG11 mutations can affect their activity too, although the impact varies with each drug’s structure. In general, any substitution that perturbs the Erg11 active site or heme pocket will reduce azole affinity and raise resistance across this drug class.

 

(Not finished regarding this niched down topic)

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