Cytochromes - Cytochomes P450 - ERG11 gene - Non-Elaborate Posts - Post 3

 

 A key reason ERG11 is medically important is that it encodes the target of azole antifungal drugs. Azoles (such as fluconazole, itraconazole, voriconazole, posaconazole, and related triazole compounds) bind to the heme iron in Erg11p and block the demethylation reaction. This inhibition starves the cell of ergosterol and causes toxic sterol accumulation, effectively killing or halting the fungus.

 

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