Cytochromes - Cytochomes P450 - ERG11 gene - Non-Elaborate Posts - Post 10

 

 ERG11 normally encodes the lanosterol 14α-demethylase essential for ergosterol production. Mutations in ERG11 change the enzyme so that it still (partially) makes sterols but no longer binds azole drugs well. 

This mechanism underlies resistance to fluconazole, voriconazole, posaconazole, and related antifungals. In resistant strains, ERG11 point mutations often appear alongside other changes (e.g. efflux pumps), but many cases of azole resistance can be directly attributed to altered Erg11p binding properties.

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