Cytochromes - Cytochomes P450 - ERG11 gene - Non-Elaborate Posts - Post 5 (Continuation ti Post 4)


Fluconazole: This common azole is highly affected by ERG11 mutations. Many clinical Candida strains that are fluconazole-resistant carry ERG11 substitutions (e.g. Y132F/H, K143R) that diminish drug binding. Studies routinely find Y132F exclusively in resistant isolates, and engineered Y132F/H enzymes show much higher fluconazole MICs.

 

(Still in the maiing for this niched diwn topic)

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