Cytochromes - Cytochomes P450 - ERG11 gene - Non-Elaborate Post - Post 7 (Continuation to Post 4 and respectively Post 6)

 

 Posaconazole (triazolopyrimidine class): Posaconazole is a broad-spectrum azole (sometimes classified as a triazolopyrimidine) with very high affinity for Erg11p. It is effective against many azole-resistant yeasts. Yet some ERG11 mutations can even overcome posaconazole. For instance, a Candida tropicalis isolate with an Y132C Erg11 substitution was resistant to posaconazole and other azoles. This shows that strong binding-site changes can confer pan-azole resistance.

 

(Nit finished regarding this niched down topic)